Animals and products derived from different organs of their bodies have constituted part of the inventory of medicinal substances used in various cultures since ancient times. The article reviews the history of healing with animals in the Levant (The Land of Israel and parts of present-day Syria, Lebanon, and Jordan, defined by the Muslims in the Middle Ages as Bilad al-Sham) in the medieval and early Ottoman periods.
Intensive research into the phenomenon of zootherapy in the medieval and early Ottoman Levant has yielded forty-eight substances of animal origin that were used medicinally. The vast majority of these substances were local and relatively easy to obtain. Most of the substances were domestic (honey, wax, silkworm, etc.), others were part of the local wildlife (adder, cuttle fish, flycatcher, firefly, frog, triton, scorpion, etc.), part of the usual medieval household (milk, egg, cheese, lamb, etc.), or parasites (louse, mouse, stinkbug, etc.). Fewer substances were not local but exotic, and therefore rare and expensive (beaver testicles, musk oil, coral, ambergris, etc.).
The range of symptoms that the substances of animal origin were used to treat was extensive and included most of the known diseases and maladies of that era: mainly hemorrhoids, burns, impotence, wounds, and skin, eye, and stomach diseases.
Changes in the moral outlook of modern societies caused the use of several substances of animal origin to cease in the course of history. These include mummy, silkworm, stinkbug, scarabees, snail, scorpion, and triton.
Since ancient times animals, their parts, and their products have constituted part of the inventory of medicinal substances used in various cultures. This phenomenon is marked by both a broad geographical distribution and very deep historical origins. As some authors have shown, animal-based medicines have been utilised since antiquity [1,2].
Testimony to the medical use of animals began to appear with the invention of writing, and is found in archives, papyruses, and other early written historical sources dealing with medicine. Data have been found on such usages in ancient civilisations, such as Egypt and Mesopotamia, which left their mark on the various societies that later arose in the Levant.
Historical sources of ancient Egypt mention the medicinal uses of substances derived from animals, for example, cattle milk, bee honey, lizard blood, ox organs, swallow’s liver, bat limbs, ambergris from the sperm whale, and the glands of the musk deer [3-6].
Archives of several civilisations of ancient Mesopotamia, mainly the Assyrian and the Babylonian, contain descriptions of fish oil, beeswax and honey, mongoose blood, turtle shell, goat’s skin, gazelle, deer and sheep sinew, bird excrement, and animal fat [7-10].
In ancient China, among many other substances of animal origin, the glands of the musk deer were used [11,12]. In India, the Hindu religion has used five products of the cow for purification since ancient times .
Classical medical literature also indicates animals as remedies. In the 5th–4th centuries BCE Hippocrates  included among many other animal substances the use of cattle milk, chicken’s eggs, mammals’ horns and sea sponge . About 10% of the substances mentioned in Dioscorides’s (1st century CE) materia medica  were body parts and products of animals [16,17]. Such uses on a smaller scale were common in the Byzantine empire .
The Jewish sources, mainly the Mishna (1st–3rd centuries CE) and the Talmud (4th – 5th centuries CE), that is, the literature of the Jewish Sages, mention several animals and their medical uses: honey was used to treat bulimia and goat’s milk to cure coughing. Snakes, human urine, pearl, mammals’ glands, and several other substances were used for different medical conditions .
The neo-Aramaic medical tradition, which evolved in the Near East during the Byzantine period, conserving classical medical knowledge, made great medical use of animals [20,21]. This knowledge was conveyed farther and translated, becoming an important part of the new Arab medical and pharmaceutical profession (7th century CE).
Arabic medieval literature offers ample information about animals in general and their medical uses in particular. The ‘medicine of the prophets’ (tibb al-nabawi) indicates intensive medicinal use of chicken eggs, cattle cheese, and bee honey [22,23], for medicinal uses of foodstuff were common in the Middle Ages, as they still are in folk medicine . Early Muslim physicians such as the 9th-century al-Tabari  and al-Kindi  describe the medical uses of several animals, in Iraq and Iran, such as bear, beaver testicles, camel, cattle fat, coral, crab, dog, fish stone, horse, lizard, medical skink, mouse, pearl, pigeon, rabbit, rhino and goat horns, scorpion, snake, squid, turtle, and wolf, and animal products such as honey, wax, milk, and eggs. Together these comprise about 7% of all medicinal substances [25,26]. More information on such uses can be found in general encyclopaedias such as that of the 13th-century al-Qazwini [14,27,28]. al-Damiri, the 14th-century Muslim zoologist , describes in his lexicon hundreds of animals , tens of which were used for remedies .
The accounts of travellers during the Middle Ages are an additional source of information about animals used for medicinal purposes. For example, Geoffrey of Unseefe (12th century) described the use of theriac against various kinds of insect bites, while Jacques de Vitry (12th–13th centuries) describes the beaver, which “bites off its own testicles with its teeth and throws them to the pursuing hunters” who make use of them for medicinal purposes. Jacques de Vitry mentions a pharmacist in Acre who raised various animals and used their excrement to prepare medications. Felix Fabri (15th century) described the hunting of the adder, which provided one of the components for theriac. Thomas Shaw (18th century) tells of the striped lizard found on the coast of Syria and used for the arousal of sexual desire .
Many of the animals which were mentioned before are also used in present-day traditional medicine. For instance, in Iraq twelve kinds of animals are described as medicinal sources, including sea sponge, cow, camel, bee, fish, squid, sheep, nacre, and silkworm, and they constitute 5% of all the substances mentioned . A survey conducted in Syria during the 1970s found that 2–8% of the substances in the possession of medicine vendors in the markets were of animal origin [33,34]. A survey of traditional materia medica in use in the markets of Israel recorded 20 substances of animal origin . Similar data are derived from surveys conducted in Jordan .
In Pakistan, for instance, 31 substances were listed (animal parts and products), constituting 9% of all the medicinal substances in the inventory of traditional medicines. Examination and research show that these substances are similar to those used as remedies throughout human history, irrespective of geographical borders, and include: sea sponge, bee honey and beeswax, squid, medical skink, lizard, silkworm, crab, spider, amber, pearl, nacre, hedgehog, and earthworm [37-39].
A study on the use of medicinal substances in the Levant during the Middle Ages found that 9.5% of all the medicinal substances were of animal origin . The primary purpose of some animal products, which were used as remedies, was food. The study also examined the reciprocal relationship of substances such as milk, cheese, and honey as food products and their use as medicinal remedies .
The importance of animal parts in the history of pharmacy in general has been studied since the beginning of the 20th century ; other works deal with groups of animals and their uses in medicine, for example, marine animals .
Tools and Methods
The present study takes a new approach to the use of animals in medicine in the medieval (10th–16th century) and early Ottoman (16th–18th century) Levant (the Land of Israel and parts of present-day Syria, Lebanon, and Jordan, defined by the Muslims in the Middle Ages as Bilad al-Sham).
Literature (primary as well as secondary) consisting of tens of diverse historical sources was screened to shed light on the medicinal uses of materials of animal origin from the 10th to the 18th century. The main sources are presented in table table 1.
The information presented in Table Table 2 is the result of a survey of literature on the medicinal substances of Bilad al-Sham (the Levant) from the 10th to the end of the 18th century [40,72]. The criteria were: (1) the animal or product is mentioned in a book on medicine or pharmacy treating the Levant or one of its cities or geographical zones. (2) It is mentioned in a source regarding trading in it in the area; and we possess other historical sources dealing with its medicinal applications in the Levant. (3) The substance is mentioned in general literature regarding its medicinal use.
Several animals and their products were disregarded since they were used by quacks or for mystical medicinal uses: these are subjects for different research, although the two fields are not always fully distinguished .
Finding the substances of animal origin in the literature was tough work, but identifying them according to their medieval names, written in many dialects, or by their nicknames was even harder, mainly because no drawings or paintings were available. Therefore, exact scientific identification was not always accomplished.
The means of identification included all old and new dictionaries, lexicons, zoology books, and scientific keys.
The sources noted in the table are those in which the substance is said to be used in the Levant. However, the medicinal uses of the substances in the medieval period were collected from other sources as well, mainly medical books of the same period [27,28,46,64,73,74]. The information presented in the table is limited, so conflicting identifications, detailed descriptions, a full list of sources, or a complete list of uses are not given.
Discussion and Conclusion
The accumulated data set out in table table 2 attest to a remarkably wide range of medicinal uses of animals and their parts in the medieval and Ottoman Levant. Recent historical surveys located and identified 286 medicinal materials, of which 81.8% are of plant origin, 5.2% of minerals, 3.5% of other materials, and 9.5% of animal origin [40,75]. Recent ethnopharmacological surveys conducted at shops and with vendors of traditional medicine in Israel  and Jordan  reveal that similar materials are in use in the same geographical area until present day.
Tables Tables 2 contains forty-eight animal extracts and products. These can be divided into three different groups:
Available Animal Substances
Apparently, the great majority of the substances were readily available to the medieval and early Ottoman physician, pharmacist, or patient as wild animals (ant, bee eater, cuttle fish [image no. 5], desert partridge, earthworm, fish, firefly, flycatcher, fox, frog, gazelle, hedgehog, lizard, scarabees, scorpion, sea shell (tallina), snail), as domesticated animals (ass, cattle [cheese – image no. 3], hen, honey and wax [image no. 1], goat, goose, lamb, mule, silkworm [image no. 2]), or as parasites of humans or domesticated animals (louse, mouse, stinkbug). The use of these substances could be explained by their abundance, which ensured fresh and cheap availability of supply.
Rare Animal Substances
Adder [image no. 4], bustard, coral, kermes, lacca, ostrich, triton and squid. These animals were hunted in season or collected in the desert, on the seashore, or in remote areas. They were rare, relatively expensive, but reasonably available.
Exotic Animal Substances
Common beaver, civet cat (zebed), musk, pearl, Spanish fly, sperm whale (ambergris), which were imported from distant lands via the trade routes and therefore were exotic . The habitats of these animals were special and found in distant places. They were very rare, and trade in them was usually a monopoly. They were very expensive.
The animal substances were applied to treat a wide range of symptoms and diseases such as skin diseases, bleeding, wounds, internal disease, haemorrhoids, animal bites, and sex-related diseases. Some of the substances listed in table table 2 were used for other purposes such as perfume (musk oil, ambergris), lighting (wax), and food (honey, cheese, chicken products, goat products).
It is assumed that in the medieval and early Ottoman Levant a larger number of animals served for medical use. Presumably, animals such as pigeons and leeches were used but are not mentioned in the sources since they were associated with magic healing or traditional medicine. Some medieval and Ottoman sources do mention these animals, but without any direct connection to the Levant.
Besides the animals and their products that were positively identified, several indications of the medicinal uses of other animal-related materials were detected.
These materials are presented here separately owing to their uniqueness:
I. Petrified spines of sea urchin (Cidaris sp.). These were used to open obstructions in the renal system and dissolve renal stones (bladder as well as kidney stones) . It seems as these specific uses were according to the doctrine of signatures . Other uses of this substance were for treating stings, bites, and wounds, and for softening hard skin [46,64,69]. This substance is presented here on account of its animal origin before the petrifaction process. During the medieval and early Ottoman period it was considered as substance of mineral origin, as it still is in present-day traditional medicine in the Levant.
II. ‘Theriak’, (theriac). This is a mixture of many medicinal substances: plants, poisonous minerals, and extracts of animals generally poisonous such as snakes and scorpions. Its preparation was considered a unique medical and pharmaceutical art . It was used in medieval and early Ottoman Levant to treat leprosy, snakes bites, scorpion stings, animal bites, and poisoning by different kinds of poisons . It was one of the special goods exported from the Holy Land during this period .
At times, the use of certain substances of animal origin was against the patient’s or the physician’s religious precepts (e.g., the internal use of snakes, louse, mummy and scorpions by Jews). Accordingly, Muslim physicians used wine as a medicinal substance even for internal use! The explanation of this phenomenon may be that the medical tradition (mainly classical) that predominated throughout ages superseded local religious norms, especially in cases of saving life or in other hazardous situations.
From a commercial point of view, we readily observe that some of the substances of animal origin were the usual goods traded in the Levant and in international commerce throughout history. Most of the imported products, such as musk, mummy, beaver, coral, and ambergris, were brought from Asia and Africa by sea and land. The majority of them were goods in transit at the Levantine cities and ports, having been sold to western traders, primarily Italians, who shipped them on to Europe. Some substances of local animal origin, such as the triton and the adder, were exported, according to the historical sources, to Egypt and other Mediterranean countries [76,80].
Out of all the historical sources that have contributed information on the use of substances of animal origin in the Levant, two should be mentioned: Daud Ibn ‘Umar al-Antaki, the 16th century Turkish physician [64-66], and Rabbi Hayyim Vital [67,68]. Each of these contributed data on the medicinal uses of nine animal substances, and both lived and practised medicine at the 16th–17th centuries – a period in which the medieval medical knowledge reached its zenith in the Levant.
The use of several materials of animal origin came to a halt in the course of history owing to a change in the moral outlook of modern societies. These materials include mummy, silkworm, goat products, stinkbug, scarabees, snail, scorpion, and triton .
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